Sinclair Method Studies
Published on: 11/06/2025
This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.
Naltrexone and The Sinclair Method in the UK and Ireland: Why Support Is Essential for Success
Bruce Rose Published on: 06/06/2025
A science-based approach called The Sinclair Method (TSM) is gaining visibility in the UK and Ireland. At its core is Naltrexone, a medication that rewires the brain’s response to alcohol.
The Sinclair Method (TSM)
Is Naltrexone Available in the UK and Ireland? What You Need to Know
Bruce Rose Published on: 28/05/2025
Naltrexone is a non-addictive opioid antagonist that blocks the brain’s ability to feel pleasure from alcohol. Over time, drinking becomes less rewarding, reducing cravings and consumption naturally — a process known as Pharmacological Extinction. This effect is the foundation of The Sinclair Method (TSM), where individuals take Naltrexone only prior to drinking, gradually reprogramming their brain’s response to alcohol.
The Sinclair Method (TSM)
What is The Sinclair Method? Discover the Gold Standard for Alcohol Recovery in the UK & Ireland
Published on: 11/04/2025
The Sinclair Method (TSM) is a medically proven approach to reducing and overcoming alcohol dependence – one that flips conventional treatment on its head. Rather than asking you to quit drinking from day one, TSM invites you to do something far simpler: take a tablet of naltrexone one hour before drinking.
The Sinclair Method (TSM)
